Anaphylaxis

🔑 Key Priorities

  • Remove trigger

  • Restore perfusion and airway protection

🧠 Team Actions

Role

Task

Team Leader

Guide severity grading and escalation

Airway Manager

Secure airway early if required

Circulation

IV access, fluid bolus, prepare adrenaline

🧭 Management Algorithm

  1. Cease suspected trigger (drug, latex, chlorhexidine)

  2. 100% O₂, stop volatile agent

  3. Administer adrenaline:

    • Grade 2: 10–50 mcg IV boluses

    • Grade 3: 100–200 mcg IV boluses

    • Grade 4: 1mg IV as for cardiac arrest

  4. Give fluid bolus: 10–20 mL/kg

  5. Start adrenaline infusion if requiring multiple boluses

  6. Add hydrocortisone 200mg ± antihistamines

  7. Consider vasopressin, noradrenaline if refractory

  8. Take serum tryptase samples at 1, 4, 24 hours

🔄 Ideal Crisis Flow

            Suspected Anaphylaxis
                    ↓
         Cease Trigger, 100% O₂, Call Help
                    ↓
        Adrenaline Bolus ± Infusion + Fluids
                    ↓
      Escalate with Vasopressors if Refractory
                    ↓
        Secure Airway + ICU + Tryptase Samples

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